We continuously develop and expand our robust pipeline to address patients' unmet medical needs. Our pursuit of new medicines is fueled by the scientific curiosity of our employees, a willingness to examine new ideas, and the pairing of existing information with novel concepts.

Please note that the medicines in the pipeline below are currently under clinical trial investigation and are not yet approved.

Pipeline Chart

* As of January 31, 2024

Pipeline Chart

 

5DXd ADCs

Phase 1 Phase 2 Phase 3 Regulatory Phase
(US/EU/Asia) HER2+ BC 2L+/1L
DESTINY-Breast07
(US/EU/Asia) TNBC 
(durvalumab combo)
BEGONIA
(JP/US/EU/Asia) HER2+ BC 
adjuvant*1
DESTINY-Breast05 
(US) HER2 expressing tumors
DESTINY-PanTumor02, DESTINY-CRC02 etc.
(US/EU/Asia) HER2 low BC 
Chemo naïve/ post chemo
DESTINY-Breast08
(CN) HER2 mutant NSCLC 2L+
DESTINY-Lung05
(JP/US/EU/Asia) HER2 low BC 
chemo naïve
DESTINY-Breast06
(CN) HER2+ GC 3L
DESTINY-Gastric06
(JP/US/EU/Asia) HER2+ GC combo, 2L+/1L
DESTINY-Gastric03
(US/EU/Asia) NSCLC
(durvalumab combo) 2L+ 
HUDSON
(JP/US/EU/Asia) HER2+ BC 1L
DESTINY-Breast09
(JP/US/EU/Asia) NSCLC 2/3L
TROPION-Lung01
(US/EU/Asia) HER2+ NSCLC  (durvalumab, MEDI5752 combo) 1L
DESTINY-Lung03
(JP/US/EU/Asia) solid tumors 
TROPION-PanTumor03
(JP/US/EU/Asia) HER2+ BC
neoadjuvant
DESTINY-Breast11
(JP/US/EU/Asia) BC*2  2/3L
TROPION-Breast01
(US/EU) BC, bladder
 (nivolumab combo)
(US/EU/Asia) TNBC
(durvalumab combo)
BEGONIA
(JP/EU/Asia) HER2+ GC 2L
DESTINY-Gastric04
(JP/US/EU/Asia) EGFR mutated 
NSCLC 3L 
HERTHENA-Lung01
(US/EU) BC, NSCLC 
(pembrolizumab combo)
(JP/US/EU/Asia) EGFR mutated 
NSCLC (osimertinib combo) 2L 
ORCHARD
(JP/US/EU/Asia) NSCLC
(w/ HER2 exon 19 or exon 20 mutation) 1L 
DESTINY-Lung04
(JP/US/EU/Asia) solid tumors
(AZD5305 combo) 
PETRA
(US/EU/Asia) resectable early-stage NSCLC (durvalumab combo) neoadjuvant 
NeoCOAST-2
(JP/US/EU/Asia) non-squamous NSCLC (w/o AGA, pembrolizumab combo) 1L 
TROPION-Lung07
(JP/US) solid tumors 
TROPION-PanTumor01
(JP/US/EU/Asia) in prep, melanoma SCCHN, HER2 negative GC, 2L+
HERTHENA-PanTumor01
(JP/US/EU/Asia) NSCLC (w/o AGA, pembrolizumab combo) 1L  
TROPION-Lung08
(CN) NSCLC, TNBC
TROPION-PanTumor02
(JP/US/EU/Asia) ES-SCLC, 2L
IDeate-Lung01 (IDeate-1)
(JP/US/EU/Asia) TNBC (PD-1/PD-L1 inhibitor ineligible) 1L
TROPION-Breast02
(JP/US/EU/Asia) NSCLC (w/o AGA, pembrolizumab combo) 
TROPION-Lung02
(JP/US/EU/Asia) in prep, ovarian, primary peritoneal, or fallopian tube cancer
REJOICE-Ovarian01
(JP/US/EU/Asia) TNBC 
(mono or durvalumab combo) adjuvant*3 
TROPION-Breast03
(JP/US/EU) NSCLC (w/o AGA, durvalumab, AZD2936 and MEDI5752 combo)
TROPION-Lung04
(JP/US/EU/Asia) TNBC neoadjuvant and adjuvant (durvalumab combo)
TROPION-Breast04
(US/EU/Asia) solid tumors 
(AZD5305 combo)
PETRA
(JP/US/EU/Asia) PD-L1 positive TNBC 1L (mono or durvalumab combo)
TROPION-Breast05
(JP/US/EU/Asia) NSCLC (JP/US/EU/Asia) EGFR mutated 
NSCLC  2L 
HERTHENA-Lung02
(JP/US) EGFR mutated NSCLC
(osimertinib combo)
(JP/US/EU/Asia) in prep, ES-SCLC, 2L+
IDeate-Lung02 (IDeate-2)
(JP/US) ESCC, CRPC, squamous NSCLC, SCLC, etc.
IDeate-PanTumor01
DS-6000 (JP/US) 
Renal cell carcinoma, ovarian cancer

T-DXd DS-7300 (I-DXd)    
Dato-DXd  DS-6000 (R-DXd)    
HER3-DXd    
Project in oncology that is planned to be submitted for approval in some countries/regions based on the results of phase 2 trials
 
Breakthrough Designation (US)   Breakthrough Designation (US) Orphan drug designation (designated in at least one country/region among JP, US and EU)  Orphan drug designation (designated in at least one country/region among JP, US and EU

*1 Adjuvant therapy for HER2 positive breast cancer patients with residual invasive disease following neoadjuvant therapy
*2 Adjuvant therapy for TNBC patients with residual invasive disease following neoadjuvant therapy
*3 HR+, HER2 low or negative BC
AGA: actionable genomic alterations, BC: breast cancer, CRC: colorectal cancer, CRPC: castration-resistant prostate cancer, ESCC: esophageal squamous cell carcinoma,
ES-SCLC: extensive stage-small cell lung cancer, GC: gastric cancer, NSCLC: non-small cell lung cancer, SCLC: small cell lung cancer, TNBC: triple negative breast cancer

Next Wave

 Phase 1 Phase 2 Phase 3 Regulatory Phase
DS-1055 (JP/US) 
Anti-GARP antibody 
Solid tumors
DS-7011 (US) 
Anti-TLR7 antibody 
Systemic lupus erythematosus 
Valemetostat (DS-3201) (EU) 
EZH1/2 inhibitor 
BCL
Pexidartinib (JP/Asia) 
CSF-1/KIT/FLT3 inhibitor 
Tenosynovial giant cell tumor
Valemetostat (DS-3201)(JP/US/EU/Asia) 
EZH1/2 inhibitor 
PTCL
DS-1594 (US) 
Menin-MLL binding inhibitor 
AML, ALL
DS-2325 (EU)
KLK5 inhibitor
Netherton syndrome
DS-1001 (JP) 
Mutant IDH1 inhibitor 
Glioma
Esaxerenone (JP) 
MR blocker 
Diabetic nephropathy
Mirogabalin (CN) 
α2δ ligands
Diabetic peripheral neuropathic pain
DS-9606 (US/EU) 
Target undisclosed ADC 
Solid tumors
DS-1211 (US/EU) 
TNAP inhibitor 
Pseudoxanthoma elasticum
VN-0102/JVC-001 (JP) 
Measles mumps rubella combined vaccine
DS-1103
Anti-SIRPα antibody
HER2 expressing or mutant advanced metastatic solid tumors, HER2 low BC (ENHERTU® combo)
VN-0200 (JP) 
RS virus vaccine 
RS virus infection
DS-5670 (JP)
COVID-19 mRNA vaccine (mutant strain),
COVID-19 (booster vaccination, 5 to 11 aged children)
DS-3939
Anti-TA-MUC1 ADC
Solid tumors
DS-5670 (JP)
COVID-19 mRNA vaccine (mutant strain), COVID-19(single dose,12 years old and over)
DS-1471
Anti-CD147 antibody
Solid tumors

Oncology

Specialty Medicine
Vaccine
Project in oncology that is planned to be submitted for approval in some countries/regions based on the results of phase 2 trials
SAKIGAKE Designation (JP) Orphan drug designation (designated in at least one country/region among JP, US, and EU
Rare Pediatric Disease Designation (US) Fast Track Designation (US)  
     
ALL: acute lymphoblastic leukemia, AML: acute myeloid leukemia, BCL: B cell lymphoma, LBCL: large B cell lymphoma, PTCL: peripheral T-cell lymphoma